2015 Fiscal Year Final Research Report
Establishment of early diagnostic system using cytological analysis of oral squamous cell carcinoma and precancerous lesion
| Project/Area Number |
25462852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKURA Masaya 大阪大学, 大学院歯学研究科, 准教授 (10281130)
SUZUMURA Yuko 大阪大学, 歯学部附属病院, 臨床検査技師 (50648748)
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| Co-Investigator(Renkei-kenkyūsha) |
MORII Eiichi 大阪大学, 大学院医学系研究科, 教授 (10283772)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 扁平上皮癌 / 前癌病変 / 細胞診 |
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| Outline of Final Research Achievements |
Collaborative research with other institutions entitled 'Study on accurate diagnostic rate in oral cytology' was performed. 423 cases of cytological specimens were used for microscopic re-examination by 11 oral cytologist. The sensitivity for detection of cancer cells was 71.5%, and its specificity was 87.0%. We created diagnostic criteria of the oral cytology with other oral cytologists.
Immunocytochemical staining method was used for detecting Galectin-1 (endogenous lectin protein) in liquid based cytology specimens. The positive ratio of Galectin-1 was higher in neoplastic lesions (79.0%) than in non-neoplastic lesions (22.0%). The sensitivity (75.0%), specificity (75.0%) and positive predictive value (91.3%) of Galectin-1 were also high in cytological specimens.
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| Free Research Field |
医歯薬学
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