The analysis of induction of aberrant AID expression and mutagenesis in TP53 in human gingival epithelial cells with carcinogenic bacteria

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462871
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Iwate Medical University
• Principal Investigator: Sasaki Minoru 岩手医科大学, 歯学部, 准教授 (40187133)
• Co-Investigator(Renkei-kenkyūsha): KIMURA SHIGENOBU 岩手医科大学, 歯学部, 教授 (10177917) ; SIMOYAMA YU 岩手医科大学, 歯学部, 助教 (90453331)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 口腔レンサ球菌 / AID / oral cancer / p53

Outline of Final Research Achievements

Streptococcus anginosus, one of the oral streptococci could be closely related with oral squamous cell carcinoma (SCC). Recent studies have revealed that the relationship between bacterial carcinogenesis and aberrant AID expression. In this study, the involvement of S. anginosus infection and the AID expression in oral SCC was demonstrated. S. anginosus genome DNA was frequently observed in the oral SCC, and the relatively higher AID expressions were detected in the cancerous region. The stimulation with S. anginosus antigen SAA could induce the AID expression through NF-kB activation in cultured epithelial cells. Further, S. anginosus SAA induced the generation of nucleotide alterations in TP53. Taken together, S. anginosus infection could be closely related with the oral SCC.

Free Research Field

医歯薬学