2015 Fiscal Year Final Research Report
Anti-inflammatory effect of MMP-3 on tissue regeneration in dental pulpitis.
| Project/Area Number |
25462882
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 歯髄炎 / MMP-3 |
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| Outline of Final Research Achievements |
In this study, to clear the mechanism of the effect of MMP-3 as anti-pulpitis drugs, we identified the MMP-3 binding protein in human dental pulp tissues. From results of analyses, versican was identified as substrate of MMP-3. On canine pulpitis model, structure and localization of versican on MMP-3 treated pulp tissue was different to control non treated tissues. In conclusion, complex of versican and hyaluronic acid was critical in recruiting of inflammatory cells, and anti-inflammatory effects of MMP-3 were closely linked to disruption of versican and hyaluronic acid.
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| Free Research Field |
形態系基礎歯科学
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