Development of drug release materials for bone regeneration

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463062
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: BABA Shunsuke 大阪歯科大学, 歯学部, 教授 (40275227)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Yoshiya 大阪歯科大学, 歯学部, 講師 (20228430) ; YAMAOKA Tetsuji 国立研究開発法人国立循環器病センター, 研究所, 部長 (50243126) ; HONDA Yoshitomo 大阪歯科大学, 歯学部, 講師 (90547259)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 薬剤徐放性担体 / 骨再生

Outline of Final Research Achievements

Basic fibroblast growth factor (bFGF) enhances the proliferation of undifferentiated mesenchymal cells, resulting in the promotion of bone formation. bFGF was immobilized on porous alpha-tricalcium phosphate (α-TCP) particles through a specific interaction with heparin.
This study demonstrates that porous α-TCP with immobilized bFGF is sufficiently adaptable for treatment of rat calvarial and canine mandibular bone defects.

Free Research Field

口腔インプラント学