Tongue muscle reconstruction using human mesenchymal stem cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463091
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Saga University
• Principal Investigator: Yamashita Yoshio 佐賀大学, 医学部, 准教授 (50322300)
• Co-Investigator(Kenkyū-buntansha): GOTO Masaaki 佐賀大学, 医学部歯科口腔外科学講座, 教授 (10145211) ; NOGUCHI Nobuhiro 佐賀県立病院好生館, 歯科口腔外科, その他 (40284658) ; SHIMOHIRA Daiji 佐賀大学, 医学部歯科口腔外科学講座, 助教 (70594844) ; DANJO Atsushi 佐賀大学, 医学部歯科口腔外科学講座, 講師 (80452712)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 間葉系幹細胞 / 筋組織 / 舌癌 / 温度感受性細胞シート

Outline of Final Research Achievements

We performed a study to regenerate muscular tissue using human mesenchymal stem cells for patients defective by treatment of tongue cancer. It was proved by animal experiments that these cells could be induced differentiation to myoblastic cells under a special environment. The clinical possibility was suggested in the future. However the ration of differentiated cells was not efficient. Improvement method is necessary. We also tried the animal experiments with layered cell sheets to use for the loss of tongue. But, our cell sheet did not really engraft on mouse tongue, since a tongue was a high flexible part.　Development of portable cell sheet is necessary near the future.

Free Research Field

再生医学