2015 Fiscal Year Final Research Report
Study of periodontal ligament tissue function about maintaining homeostasis and regeneration in periodontal tissues, and development of new regeneration therapy in periodontal tissues.
| Project/Area Number |
25463182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Yoshitaka 北海道大学, 歯学研究科(研究院), 准教授 (30230816)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | SDF-1 / 乳歯 / 歯根膜 / FGF-2 |
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| Outline of Final Research Achievements |
SDF1 plays an important role in tissue regeneration, repair and homeostasis by attracting mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs). While periodontal tissues are exposed to occlusal force, injury and orthodontic force, it is unknown whether periodontal ligament(PDL) could express SDF1. Therefore, in this study, we analyzed whether PDL cells could express SDF1.
SDF1 was produced by PDL cells. SDF1 in conditioned media could induce migration of MSCs. Moreover, treatment with FGF2 suppressed SDF1 mRNA. In conclusion, we demonstrate that PDL cells may be important for maintaining the homeostasis of PDL tissue by controlling the migration of postnatal stem cells, e.g., MSCs and EPCs, to the required sites via SDF1. Several other cytokines like FGF2 may be crucial for SDF1 expression and thus also for cell-based tissue regeneration. These findings may facilitate our understanding of the mechanisms of homeostasis in the PDL tissues via SDF1 expression.
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| Free Research Field |
小児歯科学
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