Novel periodontal therapy using nanocarbon coating procedure

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463210
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Hokkaido University
• Principal Investigator: Miyaji Hirofumi 北海道大学, 大学病院, 講師 (50372256)
• Co-Investigator(Kenkyū-buntansha): TANAKA SAORI 北海道大学, 北海道大学病院, 講師 (90344522) ; KATO AKIHITO 北海道大学, 歯学研究科(研究院), 助教 (40507571)
• Co-Investigator(Renkei-kenkyūsha): FUGETSU BUNSHI 東京大学, 政策ビジョン研究センター, 特任教授 (40281844)
• Research Collaborator: NISHIDA ERIKA 北海道大学, 北海道大学病院, 医員
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ナノカーボン / カーボンナノチューブ / 酸化グラフェン / バイオマテリアル / 骨再生 / 歯周組織再生 / 抗菌性 / スキャフォールド

Outline of Final Research Achievements

Biocompatibility tests were performed to evaluate the biological properties of nanocarbon materials, such as graphene oxide (GO) and carbon nanotube (CNT). In addition, tooth coating procedure using GO and regenerative scaffold including GO were developed for application to periodontal therapy. Low dose of GO and CNT consistently exhibited good biocompatibility, in particular, CNT stimulated cell proliferative activity. The tooth coating procedure using GO solution provided the antimicrobial effect to the tooth surface. GO scaffold exhibited cytocompatibility and promoted tissue healing and bone formation when implanted in tooth extraction socket or furcation periodontal defect in dog. Consequently, nanocarbon materials would be available for medical application in periodontal therapy.

Free Research Field

歯周病学