Development of innovative embolization materials using supramolecular hydrogels

2014 Fiscal Year Final Research Report

• Project/Area Number: 25620100
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Polymer chemistry
• Research Institution: Osaka University
• Principal Investigator: TAKASHIMA Yoshinori 大阪大学, 理学(系)研究科(研究院), 助教 (40379277)
• Co-Investigator(Kenkyū-buntansha): OSUGA Keigo 大阪大学, 医学研究科, 講師 (90332741) ; HIDAKA Kuniyuki 大阪大学, 医学部附属病院, 診療放射線技師 (50437430)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 血管内塞栓物質 / 超分子ヒドロゲル / 超分子材料 / 刺激応答性材料 / 自己修復性材料 / ホストｰゲスト相互作用 / シクロデキストリン / 高靭性材料

Outline of Final Research Achievements

In the area of the endovascular treatment, the development and the clinical application have been widely used due to the high the therapeutic effect for cancer and tumor. In this research project, we have focused on supramolecular materials to apply the endovascular treatment. To prepare functional embolization materials, cyclodexterins (CDs) have been introduced into the supramolecular materials. By the introduction of CD molecules into the materials, we have successfully prepared the endovascular embolized supramolecular materials with drug delivery, self-healable, and high-elastic properties. Especially, self-healing and self-repairing materials formed by host-guest interactions recover to the initial strength even after the materials were cut in half, and then rejoined.
Moreover, we have prepared the high elastic supramolecular materials to show the reversible elastic deformation without breaking.

Free Research Field

高分子科学