Does treatment of blood flow decrease, a complication of neuropathic pain, can be a target of pain palliation?

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670041
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pharmacology in pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: Saito Shin-ya 静岡県立大学, 薬学部, 准教授 (80271849)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 神経因性疼痛 / 皮膚血管 / 電位依存性Caチャネル / Na/Ca交換体 / 血管拡張 / 温度依存性

Outline of Final Research Achievements

Dependence on voltage-dependent Ca channel (VDCC) is relatively low in skin artery comparing with other arteries. This may account for its tolerance on low temperature, since activity of VDCC is decrease in low temperature. In sciatic nerve-injured model rat, damage of sympathetic nerve is accompanied with decrease of Ca extrusion in planter artery, which results in increase of response to contractile stimuli. This suggests that weak stimuli are enough to induce sufficient contraction in injured site. According to this opinion, we administrated low dose of vasodilator which showed vasodilation with increase in pain threshold. In this study, we demonstrated that treatments which cause vasodilating response can be tools for treatment of pain.

Free Research Field

循環器薬理学