2013 Fiscal Year Annual Research Report
Project/Area Number |
25670390
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Research Institution | The University of Tokushima |
Principal Investigator |
佐田 政隆 徳島大学, ヘルスバイオサイエンス研究部, 教授 (80345214)
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Project Period (FY) |
2013-04-01 – 2014-03-31
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Keywords | 心移植 / 心筋症 / 脂肪組織 / 脂肪移植 / 慢性炎症 / 動脈硬化 / バイパス手術 / 血行再建 |
Research Abstract |
ヒトびまん性冠動脈病変の組織学的解析においては、血管壁における増強した慢性炎症を基盤としており、そこには、マクロファージやTリンパ球の浸潤が認められ、病変内血管新生が亢進していることが明らかとなった。また、慢性炎症は血管壁のみでなく、冠動脈を覆う心臓周囲脂肪組織にも波及していた。心臓周囲脂肪に浸潤しているマクロファージのサブタイプを解析したところ、炎症性であるM1型/抗炎症性M2型の比率は冠動脈疾患患者で上昇しており、Gesini score で評価した冠動脈疾患の重症度と良好に相関していた。 そこで、慢性炎症を生じている冠動脈周囲の脂肪組織を、炎症の程度が軽い自己の皮下脂肪に置換して、びまん性病変で心移植しか従来治療法がないとされたきた重症虚血性心筋症患者に対して、心臓移植の代替になるような革新的血行再建術の開発を行うことにした。 まず、マウス大腿動脈のワイヤー傷害モデルにおいて、周囲脂肪組織が病変形成に及ぼす影響を検討した。GFPマウス由来の脂肪を移植して、脂肪組織が移植4週後、血管周囲に内因性の脂肪と同様に定着し、血管壁と毛細血管で物理的連携をとっていることを確認した。痩せたマウスの皮下脂肪移植では病変形成が抑制され、肥満マウスの内臓脂肪移植では病変形成が促進されることがわかった。また、このような病変への悪影響は、炎症性アディポサイトカインの発現増強や抗炎症性アディポサイトカインの発現低下と相関していた。 以上の基礎的な裏付けをもとに、びまん性冠動脈病変に対して、血管と脂肪移植による新規血行再建術の研究を着手した。豚にバルーンと高脂肪食で、びまん性の冠動脈病変を作成するモデル開発を開始した。
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[Journal Article] Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model.2013
Author(s)
Hirata Y, Kurobe H, Uematsu E, Yagi S, Soeki T, Yamada H, Fukuda D, Shimabukuro M, Nakayama M, Matsumoto K, Sakai Y, Kitagawa T, Sata M.
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Journal Title
Eur J Pharmacol.
Volume: 699
Pages: 81-87
DOI
Peer Reviewed
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[Journal Article] Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury.2013
Author(s)
Hirata Y, Kurobe H, Nishio C, Tanaka K, Fukuda D, Uematsu E, Nishimoto S, Soeki T, Harada N, Sakaue H, Kitagawa T, Shimabukuro M, Nakaya N, Sata M.
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Journal Title
Eur J Pharmacol.
Volume: 699
Pages: 106-111
DOI
Peer Reviewed
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[Journal Article] Eosinophilic myocarditis due to churg-strauss syndrome with markedly elevated eosinophil cationic protein.2013
Author(s)
Hara T, Yamaguchi K, Iwase T, Kadota M, Bando M, Ogasawara K, Bando S, Ise T, Niki T, Ueda Y, Tomita N, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Sata M.
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Journal Title
Int Heart J.
Volume: 54
Pages: 51-53
DOI
Peer Reviewed
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[Journal Article] Constrictive pericarditis with intrapericardial abscess.2013
Author(s)
Hara T, Yamada H, Takashima A, Yamasaki H, Ogasawara K, Bando S, Ise T, Niki T, Kusunose K, Ueda Y, Tomita N, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Horiguchi H, Sakashita N, Sata M.
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Journal Title
Circ J.
Volume: 77
Pages: 786-788
DOI
Peer Reviewed
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[Journal Article] Perivascular adipose tissue-secreted angiopoietin-like protein2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury.2013
Author(s)
Tian Z, Miyata K, Tazume H, Sakauguchi H, Kadomatsu T, Horio E, Takahashi O, Komohara Y, Araki K, Hirata Y, Tabata M, Takanashi S, Takeya M, Hao H, Shimabukuro M, Sata M, Kawasuji M, Oike Y.
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Journal Title
J Mol Cell Cardiol.
Volume: 57
Pages: 1-12
DOI
Peer Reviewed
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[Journal Article] Ectopic fat deposition and global cardiometabolic risk: New paradigm in cardiovascular medicine.2013
Author(s)
Shimabukuro M, Kozuka C, Taira T, Yabiku K, Dagvasumberel M, Ishida M, Matsumoto S, Yagi Y, Fukuda D, Yamakawa K, Higa M, Soeki T, Yoshida H, Masuzaki H, Sata M.
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Journal Title
J Med Invest.
Volume: 60
Pages: 1-14
Peer Reviewed
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[Journal Article] Interval from the onset of transmitral flow to annular velocity is a marker of LV filling pressure.2013
Author(s)
Kusunose K, Yamada H, Nishio S, Tomita N, Niki T, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Sata M.
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Journal Title
JACC Cardiovasc Imaging.
Volume: 6
Pages: 528-530
DOI
Peer Reviewed
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[Journal Article] Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis.2013
Author(s)
Shimabukuro M, Hirata Y, Tabata M, Dagvasumberel M, Sato H, Kurobe H, Fukuda D, Soeki T, Kitagawa T, Takanashi S, Sata M.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 33
Pages: 1077-1084
DOI
Peer Reviewed
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[Journal Article] Two cases of acute myocardial infarction during combined chemotherapy in young patients with testicular cancer.2013
Author(s)
Kawano N, Yamaguchi K, Niki T, Yamamoto T, Iwase T, Taketani T, Ise T, Yamada H, Soeki T, Wakatsuki T, Kawano K, Kakutani K, Sata M.
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Journal Title
JC Cases.
Volume: 7
Pages: e176-e180
DOI
Peer Reviewed
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[Journal Article] Pharmacology of aldosterone and the effects of mineralocorticoid receptor blockade on cardiovascular systems.2013
Author(s)
Yagi S, Akaike M, Aihara KI, Fukuda D, Ishida M, Ise T, Niki T, Sumitomo-Ueda Y, Yamaguchi K, Iwase T, Taketani Y, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
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Journal Title
Acta Cardiol Sin.
Volume: 29
Pages: 201-207
Peer Reviewed
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[Journal Article] Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling.2013
Author(s)
Yoshida S, Aihara KI, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama KI, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T.
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Journal Title
Circulation.
Volume: 128
Pages: 60-71
DOI
Peer Reviewed
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[Journal Article] Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodeling.2013
Author(s)
Nakayama T, Kurobe H, Sugasawa N, Kinoshita H, Higashida M, Matsuoka Y, Yoshida Y, Hirata Y, Sakata M, Maxfield MW, Shimabukuro M, Takahama Y, Sata M, Toshiaki T, Tetsuya K, Tomita S.
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Journal Title
Cardiovasc Res.
Volume: 99
Pages: 705-715
DOI
Peer Reviewed
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[Journal Article] Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model.2013
Author(s)
Shimamura M, Nakagami H, Sata M, Takaoka M, Azuma J, Kiomy Osako M, Koriyama H, Kurinami H, Wakayama K, Miyake T, Morishita R.
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Journal Title
J Cereb Blood Flow Metab.
Volume: 33
Pages: 1153-1159
DOI
Peer Reviewed
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[Journal Article] Miglitol, α-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: A randomized comparable study.2013
Author(s)
Shimabukuro, M., Higa, M., Yamakawa, K., Masuzaki, H., Sata, M.
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Journal Title
Int J Cardiol.
Volume: 167
Pages: 2108-2118
DOI
Peer Reviewed
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[Journal Article] Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein.2013
Author(s)
Soeki T, Niki T, Uematsu E, Bando S, Matsuura T, Kusunose K, Ise T, Ueda Y, Tomita N, Yamaguchi, K, Koshiba K, Yagi S, Fukuda D, Taketani Y, Iwase T, Yamada H, Wakatsuki T, Akaike M, Shimabukuro M, Kishimoto I, Kangawa K, Sata M.
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Journal Title
Heart Vessels.
Volume: 28
Pages: 795-801
DOI
Peer Reviewed
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[Journal Article] Effects of telmisartan on inflammatory cytokines and the coronary plaque component as assessed on integrated backscatter intravascular ultrasound in hypertensive patients.2013
Author(s)
Yamaguchi K, Wakatsuki T, Soeki T, Niki T, Taketani Y, Oeduka H, Kusunose K, Ise T, Iwase T, Yamada H, Sata M.
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Journal Title
Circ J.
Volume: 78
Pages: 240-247
DOI
Peer Reviewed
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[Presentation] Right ventricular systolic dysfunction in patients with exercise-induced pulmonary hypertension associated with connective tissue disease.2014
Author(s)
Saijo Y, Yamada H, Hotchi J, Nishio S, Hayashi S, Bando M, Hirata Y, Amano R, Ise T, Yagi S, Yamaguchi K, Iwase T, Soeki T, Wakatsuki T, Sata M.
Organizer
ACC 2014
Place of Presentation
The Walter E.Washington Convention Center, Washington D.C, America
Year and Date
20140329-20140331
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[Presentation] Relationship between Local Production of microRNA-328 and Atrial Substrate Remodeling in Atrial Fibrillation.2014
Author(s)
Soeki T, Bando S, Matsuura T, Tobiume T, Hara T, Ota R, Takashima A, Bando M, Ogasawara K, Saito Y, Ise T, Hotchi J, Kimura E, Yamaguchi K, Yagi S, Fukuda D, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム・JPタワーホール&カンファレンス、東京都
Year and Date
20140321-20140323
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[Presentation] Increased Local Production of C-type Natriuretic Peptide in Patients with Vasospastic Angina.2014
Author(s)
Matsuura T, Soeki T, Ota R, Hara T, Saito Y, Ogasawara K, Takashima A, Bando M, Bando S, Hotchi J, Kimura E, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Wakatsuki T, Sata M.
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム・JPタワーホール&カンファレンス、東京都
Year and Date
20140321-20140323
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[Presentation] Impact of Cardiac Rehabilitation on Oxidized Stress in Patients with Heart Failure.2014
Author(s)
Ise T, Yagi S, Iwase T, Akaike M, Takashima A, Bando M, Bando S, Matsuura T, Hotchi J, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuiki T, Sata M.
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム・JPタワーホール&カンファレンス、東京都
Year and Date
20140321-20140323
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[Presentation] Parallel Changes in Sonographic Characteristics of Carotid and Coronary Plaques.2014
Author(s)
Bando M, Yamada H, Nishio S, Hotchi J, Hayashi S, Kimura E, Ise T, Matsuura T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Soeki T, Wakatsuki T, Sata M.
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム・JPタワーホール&カンファレンス、東京都
Year and Date
20140321-20140323
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[Presentation] Differential Responses of Local Coagulation after Implantation of Biolimus-Eluting and Everolimus-Eluting Stents Compared with Sirolimus-Eluting and Bare Metal Stents.2014
Author(s)
Yamaguchi K, Wakatsuki T, Hara T, Ogasawara K, Bando M, Takashima A, Bando S, Matsuura T, Ise T, Hotchi J, Tobiume T, Yagi S, Iwase T, Yamada H, Soeki T, Sata M.
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム・JPタワーホール&カンファレンス、東京都
Year and Date
20140321-20140323
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[Presentation] Ghrelin Ameliorates the Progression of Experimental Autoimmune Myocarditis.2014
Author(s)
Bando S, Soeki T, Hara T, Takashima A, Bando M, Ogasawara K, Saito Y, Matsuura T, Hotchi J, Kimura E, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Kangawa K, Sata M.
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム・JPタワーホール&カンファレンス、東京都
Year and Date
20140321-20140323
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[Presentation] Atrial Late Potentials and Atrial Substrate Remodeling in Patients with Atrial Fibrillation.2014
Author(s)
Bando S, Soeki T, Matsuura T, Tobiume T, Hara T, Takashima A, Bando M, Ogasawara K, Saito Y, Hotchi J, Kimura E, Ise T, Yamaguchi K, Yagi S, Iwase T, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム・JPタワーホール&カンファレンス、東京都
Year and Date
20140321-20140323
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[Presentation] Periadventitial Adipose Tissue Secreted-Angiopoietin-like Protein 2 (Angptl2) Aggravates Neointimal Hyperplasia in Endovascular Wire Injury Model.2014
Author(s)
Tian Z, Miyata K, Tadume H, Horio E, Sakaguchi H, Hao H, Tabata M, Takanashi S, Shimabukuro M, Sata M, Kawasuji M, Oike Y.
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム・JPタワーホール&カンファレンス、東京都
Year and Date
20140321-20140323
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[Presentation] Right ventricular dysfunction in patients with exercise-induced pulmonary hypertension associated with connective tissue disease : an assessment using tricuspid annular motion velocities.2013
Author(s)
Hotchi J, Yamada H, Nishio S, Bando M, Hayashi S, Hirata Y, Amano R, Soeki T, Wakatsuki T, Sata M.
Organizer
Euro Echo Imaging 2013
Place of Presentation
Istanbul Lutfi Kirdar Convention & Exhibition Centre, Istanbul, Turkey
Year and Date
20131211-20131214
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[Presentation] Post-Transcriptional Regulation of Adiponectin by Micro-RNA 378 in Human Visceral and Subcutaneous Adipose Tissue.2013
Author(s)
Ishida M, Shimabukuro M, Yagi S, Fukuda D, Soeki T, Sato H, Uematsu E, Izaki H, Kanayama H, Sata M.
Organizer
AHA Scientific Sessions 2013
Place of Presentation
Dallas Convention Center, Dallas, America
Year and Date
20131116-20131120
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[Presentation] Time-dependent Changes Of Local Vascular Response And Angiographic Peri-stent Contrast Staining Up To Five Years After Zotarolimus-eluting, Sirolimus-eluting, And Bare Metal Stent Implantation.2013
Author(s)
Yamaguchi K, Wakatsuki T, Ise T, Tobiume T, Yagi S, Iwase T, Yamada H, Soeki T, Sata M.
Organizer
AHA Scientific Sessions 2013
Place of Presentation
Dallas Convention Center, Dallas, America
Year and Date
20131116-20131120
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[Presentation] Decreased Local Hypercoagulation after Implantation of Everolimus-Eluting and Zotarolimus-Eluting Stents Compared with Early-Generation Drug-Eluting Stents in patients with stable angina.2013
Author(s)
Yamaguchi K, Wakatsuki T, Ise T, Tobiume T, Yagi S, Iwase T, Yamada H, Soeki T, Sata M.
Organizer
AHA Scientific Sessions 2013
Place of Presentation
Dallas Convention Center, Dallas, America
Year and Date
20131116-20131120
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[Presentation] Impact Of Indoxy1 Sulfate, A Uremic Toxin, On Non-culprit Coronary Plaque Composition Assessed By Integrated Backscatter Intravascular Ultrasound In Patients With Coronary Artery Disease.2013
Author(s)
Yamaguchi K, Soeki T, Wakatsuki T, Ise T, Tobiume T, Yagi S, Iwase T, Yamada H, Sata M.
Organizer
AHA Scientific Sessions 2013
Place of Presentation
Dallas Convention Center, Dallas, America
Year and Date
20131116-20131120
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[Presentation] Rivaroxaban, A Novel Oral Anticoagulant, Attenuates Plaque Progression in ApoE-Deficient Mice Through the Inhibition of Pro-Inflammatory Activation of Macrophages.2013
Author(s)
Hara T, Fukuda D, Tanaka K, Higashikuni Y, Hirata Y, Ise T, Tobiume T, Yamaguchi K, Yagi S, Iwase T, Yamada H, Soeki T, Wakatsuki T, Shimabukuro M, Sata M.
Organizer
AHA Scientific Sessions 2013
Place of Presentation
Dallas Convention Center, Dallas, America
Year and Date
20131116-20131120
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[Presentation] Noninvasively Obtained Augmentation Index is Not a Reliable Maker for Vascular Sclerosis in Elderly Subjects.2013
Author(s)
Hayashi S, Yamada H, Hotchi J, Bando M, Ise T, Yamaguchi K, Iwase T, Soeki T, Wakatsuki T, Sata M.
Organizer
AHA Scientific Sessions 2013
Place of Presentation
Dallas Convention Center, Dallas, America
Year and Date
20131116-20131120
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[Presentation] Macrophage-Specific Hypoxia-Inducible Factor (HIF)-1α-Deficient Mice Suppress the Vascular Remodeling and Regulate M2 Macrophage Polarization.2013
Author(s)
Nakayama T, Kurobe H, Sugasawa N, Kinoshita H, Yoshida Y, Hirata Y, Sakata M, Maxfield MW, Shimabukuro M, Takahama Y, Sata M, Tamaki T, Kitagawa T, Tomita S.
Organizer
AHA Scientific Sessions 2013
Place of Presentation
Dallas Convention Center, Dallas, America
Year and Date
20131116-20131120
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[Presentation] Echocardiographic epicardial adipose tissue thickness in anterior interventricular groove is a marker for the presence and severity of coronary artery disease.2013
Author(s)
Hirata Y, Yamada H, Nishio S, Bando M, Hayashi S, Hotchi J, Tomofuji T, Soeki T, Wakatsuki T, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] Cardiospecific microRNA plasma levels are associated with coronary plaque vulnerability.2013
Author(s)
Soeki T, Yamaguchi K, Bando S, Matsuura T, Uematsu E, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] MicroRNA miR-378 regulates adipocytokine fate by targeting transcriptional factors in human visceral and subctaneous adipose tissue.2013
Author(s)
Ishida M, Shimabukuro M, Yagi S, Fukuda D, Soeki T, Sato H, Uematsu E, Izaki H, Kanayama H, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] MicroRNA-100 regulates a cluster of adipocytokine expression: A human biopsy study in subcutaneous and visceral adipose tissue.2013
Author(s)
Ishida M, Shimabukuro M, Yagi S, Fukuda D, Soeki T, Sato H, Uematsu E, Izaki H, Kanayama H, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] Genetic ablation of TLR9 improves insulin resistance through macrophage accumulation in adipose tissue.2013
Author(s)
Nishimoto S, Fukuda D, Shimabukuro M, Matsumoto S, Ishida M, Yagi S, Soeki T, Sakaue H, Nakaya Y, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] Differential responses of local coagulation after implantation of everolimus-eluting and zotarolimus-eluting stents compared with early-generation drug-eluting stents in patients with stable angina.2013
Author(s)
Yamaguchi K, Wakatsuki T, Niki T, Taketani Y, Ise T, Yagi S, Iwase T, Yamada H, Soeki T, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] Visceral fat mass is associated with daily physical activity, leg skeletal muscle mass and fiber intake in healthy men.2013
Author(s)
Nishikawa K, Yagi S, Ise T, Ueda Y, Iwase T, Akaike M, Shimabukuro M, Kato S, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] The tissue characteristics of coronary plaque with microchannel structure assessed by optical coherence tomography associated with local inflammatory response.2013
Author(s)
Wakatsuki T, Yamaguchi K, Niki T, Taketani Y, Ise T, Iwase T, Yamada H, Soeki T, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] Electrophysiological correlation and prognostic impact of pentraxin 3 as a local inflammatory marker in atrial fibrillation.2013
Author(s)
Soeki T, Bando S, Matsuura T, Uenmatsu E, Yamaguchi K, Iwase T, Yamada H, Wakatsuki T, Shimabukuro M, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] Ghrelin ameliorates the progression of experimental autoimmune myocarditis.2013
Author(s)
Bando S, Soeki T, Uematsu E, Matsuura T, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Kangawa K, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] Differentiation of left ventricular systolic dysfunction related to cardiac sarcoidosis and other heart diseases using contrast-enhanced cardiovascular magnetic resonance.2013
Author(s)
Iwase T, Takao T, Akaike M, Ise T, Yagi S, Yamaguchi K, Yamada H, Nishioka Y, Harada M, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] Plasma Brain Natriuretic Peptide (BNP) level is elevated in patients with cancer.2013
Author(s)
Bando S, Soeki T, Matsuura T, Yagi S, Fukuda D, Yamada H, Wakatsuki T, Shimabukuro M, Kangawa K, Sata M.
Organizer
ESC Congress 2013
Place of Presentation
Amsterdam RAI, Amsterdam, Netherlands
Year and Date
20130831-20130904
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[Presentation] Clinical Significance of Mitral L-wave in Patients with Atrial Fibrillation and Preserved Ejection Fraction.2013
Author(s)
Nakagawa M, Yamada H, Nishio S, Hayashi S, Hotchi J, Bando M, Hirata Y, Tomofuji T, Sata M.
Organizer
ASE 2013
Place of Presentation
Minneapolis Convention Center, Minneapolis, America
Year and Date
20130630-20130703
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