Screening of Flu Alarmin biomarkers of severe influenza virus infection and their confirmation in animal model

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670466
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: The University of Tokushima
• Principal Investigator: KIDO Hiroshi 徳島大学, 疾患酵素学研究センター, 特任教授 (50144978)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 重症度 / ATP / 乳酸 / リアルタイム・バイオマーカー / エネルギー代謝 / 代謝障害 / 予後判定 / サイトカイン

Outline of Final Research Achievements

Influenza A virus (IAV) causes significant morbidity and mortality. We found that energy metabolic disorder is a principal cause of multiorgan failure in severe influenza virus infection. Among the analyzed biomarkers in the blood, lactate/ATP ratio is a useful and prognostic biomarker of the disease severity in animal model and clinical data. In addition, we established SmartAmp system for detection of thermolabile carnitine palmitoyltransferase 2 SNPs as risk factors for influenza associated encephalopathy in the infected young children.

Free Research Field

病態医化学研究