A Novel strategy of radiosensitization using titan peroxide nanoparticles

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670535
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: SASAKI RYOHEI 神戸大学, 医学部附属病院, 教授 (30346267)
• Co-Investigator(Kenkyū-buntansha): OGINO Chiaki 神戸大学, 工学(系)研究科(研究院), 准教授 (00313693) ; SATO Kazuyoshi 群馬大学, その他(部局等), 助教 (40437299) ; NUMAKO Chiya 千葉大学, 理学(系)研究科(研究院), 准教授 (80284280) ; NAKAYAMA Masao 神戸大学, 医学(系)研究科(研究院), 研究員 (60582004) ; AKASAKA Hiroaki 神戸大学, 医学部附属病院, 助教 (20707161)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 放射線増感 / ナノ粒子

Outline of Final Research Achievements

The tumor growth inhibitory effects ofPAA-TiOx nanoparticles combined with X-ray irradiation was observed in vitro and in vivo experiments.The effect was induced by ROS generation followed by DNA damages in cancer cells. Evaluations of long-term toxicity and of molecular mechanisms need to be performed in the nearest future. This strategy might be a novel radiosensitization method using metal nanoparticles

Free Research Field

放射線腫瘍学