Strategy for neuroprotective effect of NO inhalation against ischemic spinal cord injury

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670599
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: University of the Ryukyus
• Principal Investigator: KAKINOHANA Manabu 琉球大学, 医学(系)研究科(研究院), 教授 (20274897)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Seiya 琉球大学, 大学院医学研究科, 准教授 (00363680) ; HIGA Tatsuya 琉球大学, 医学部附属病院, 助教 (10404568) ; IZUMI Shunsuke 琉球大学, 医学部附属病院, 助教 (90649401)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 一酸化窒素 / 脊髄虚血 / 遅発性脊髄障害 / 側副血行路 / 亜硝酸ナトリウム

Outline of Final Research Achievements

In this study, we investigated the neuroprotective effects of sodium nitrite or NO inhalation therapy against ischemic spinal cord injury. The results of in this study demonstrated that enhancement of collateral network by sodium nitrite, but not NO inhalation, could produce significant increase in spinal cord blood flow during spinal cord ischemia. However, this increase in spinal cord blood flow could not induce neuroprotection against spinal cord ischemia.

Free Research Field

麻酔科学