MS imaging Analysis to identify protein expressions regulating malignant transformation in glioma

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670623
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: SUSUMU Miyamoto 京都大学, 医学(系)研究科(研究院), 教授 (70239440)
• Co-Investigator(Kenkyū-buntansha): ARAKAWA Yoshiki 京都大学, 大学院医学研究科, 助教 (20378649)
• Co-Investigator(Renkei-kenkyūsha): FUMIHIKO Matsuda 京都大学, 大学院医学研究科, 教授 (50212220)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 神経膠腫 / 悪性転化 / MSイメージング / 質量分析

Outline of Final Research Achievements

The aim of the research project is to screen protein expressions associated with malignant transformation in glioma, to identify the driver proteins, and to reveal the novel mechanism. We evaluated the pretreatment conditions for MS imaging and visualized the protein expressions of clinical samples. To identify the proteins detected by MS imaging, the pretreatment conditions for LC/MS/MS analysis was examined. As preliminary results, we identified some proteins which has been known to be involved in gliomagenesis.

Free Research Field

脳神経外科