Pore design for the microporous covered stents to maintain blood flow in branching arteries after stenting

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670628
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: NAKAYAMA Yasuhide 独立行政法人国立循環器病研究センター, 研究所, 室長 (50250262)
• Co-Investigator(Kenkyū-buntansha): NAKAYAMA Atsuyoshi 独立行政法人産業技術総合研究所, 研究員 (10357676)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ステント / 脳動脈瘤 / 血管内治療

Outline of Final Research Achievements

The treatment of large wide-necked cerebral aneurysms is extremely difficult. The covered stents were prepared using balloon-expandable stents by dip-coating to completely cover their struts with polyurethane film and microprocessing to form the honeycomb pattern after expansion. In an the large, wide-necked, outer-sidewall aneurysm canine model, almost all parts of the aneurysms had embolized immediately after stenting, and histological examination at 2 months revealed neointimal formation with complete endothelialization at all stented segments and entirely organized aneurysms. In a perforating artery rabbit model, the lumbar arteries remained patent, with minimal change in the vascular flow pattern, even after placement of a second, overlapping stent. Excellent embolization performance of the designed microporous covered stents without disturbing branching flow was confirmed at the aneurysms in this pilot examination.

Free Research Field

医療機器工学