2014 Fiscal Year Annual Research Report
子宮頸癌発生過程とHLAクラスIIアレルに関する研究
| Project/Area Number |
25670693
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| Research Institution | University of Tsukuba |
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Principal Investigator |
吉川 裕之 筑波大学, 医学医療系, 教授 (40158415)
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| Co-Investigator(Kenkyū-buntansha) |
前田 平生 埼玉医科大学, 医学部, 教授 (30134597)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 子宮頸がん / ヒトパピローマウイルス（HPV) / ヒト白血球型抗原（HLA) |
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| Outline of Annual Research Achievements |
日本人においてHLAクラスIIと子宮頸癌もしくはその前駆病変の関連について研究することを目的として、健常者341名、CIN1/2患者591名、CIN3/子宮頸癌321名を含む1253名の日本人女性を対象として、横断的研究を行い、加えて、CIN1/2患者のうち454名については、経過観察し、CIN 3への進展とHLAクラスIIとの関連についてコホート研究も行った。結果は次のようになった。HLAクラスIIアレル頻度は、健常者とCIN1/2患者では同様であった。健常者およびCIN1/2患者と比べて、DRB1*0901、DRB1*1302の頻度はCIN3/子宮頸癌患者に比べて、有意に低かった（P=0.00001, P=0.006）。454名のCIN1/2患者の経過観察データからは、10年間のCIN3への進展リスクは、DRB1*1302患者で有意に減少していた（3.2% vs. 23.7%, P=0.03）。DRB1*0901など他のHLAクラスIIアレルとは関連がなかった。横断的研究とコホート研究により、DRB1*1302アレルがCIN3/子宮頸癌への進展を予防する効果を有することを示した。他のHLAクラスIIと子宮頸癌との関連性については確認できなかった。
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Research Products
(24 results)
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[Journal Article] Administration of standard-dose BEP regimen (bleomycin + etoposide + cisplatin) is essential for treatment of ovarian yolk sac tumor.2015
Author(s)
Satoh T, Aoki Y, Kasamatsu T, Ochiai K, Takano M, Watanabe Y, Kikkawa F, Takeshima N, Hatae M, Yokota H, Saito T, Yaegashi N, Kobayashi H, Baba T, Kodama S, Saito T, Sakuragi N, Sumi T, Kamura T and Yoshikawa H.
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Journal Title
Eur J Cancer.
Volume: 51
Pages: 340-351
DOI
Peer Reviewed
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[Journal Article] Pathology-oriented treatment strategy of malignant ovarian tumor in pregnant women: analysis of 41 cases in Japan.2014
Author(s)
Morikawa A, Ueda K, Takahashi K, Fukunaga M, Iwashita M, Kobayashi Y, Takechi K, Umezawa S, Terauchi F, Kiguchi K, Aoki D, Nomura H, Yoshikawa H, Satoh T, Jobo T, Fujiwara H, Takei Y, Kamoi S, Terao Y, Isonishi S.
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Journal Title
Int J Clin Oncol.
Volume: 19
Pages: 1074-1079
DOI
Peer Reviewed
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[Journal Article] Monitoring the impact of a national HPV vaccination program in Japan (MINT study): rationale, design and methods.2014
Author(s)
Matsumoto K, Yaegashi N, Iwata T, Ariyoshi K, Fujiwara K, Shiroyama Y, Usami T, Kawano Y, Horie K, Kawano K, Noda K, Yoshikawa H for MINT Study Group
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Journal Title
Jpn J Clin Oncol.
Volume: 44
Pages: 1000-1003
DOI
Peer Reviewed
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[Presentation] Delivery delay with neoadjuvant chemotherapy for patients with FIGO stage Ib1 cervical cancer during pregnancy: A report of two cases.2014
Author(s)
Tenjimbayashi Y, Minaguchi T, Matsumoto K, Sakurai M, Onuki M, Ochi H, Obata M, Satoh T, Hamada H, Yoshikawa H.
Organizer
The 15th Biennial Meeting of the International Gynecologic Cancer Society
Place of Presentation
Melbourne, Australia,
Year and Date
2014-11-08 – 2014-11-11
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[Presentation] A cohort study of gastric-type adenocarcinoma (GAS) of the uterine cervix: Multi-institutional study by Gynecologic Cancer Study Group of the Japan Clinical Oncology Group (JCOG).2014
Author(s)
Nishio S, Mikami Y, Otsuki T, Yaegashi N, Satoh T, Yoshikawa H, Saito M, Okamoto A, Kasamatsu T, Miyamoto T, Shiozawa T, Yoshioka Y, Konishi I, Kojima A, Nogawa T, Kaneki E, Kobayashi H, Uhsijima K, Kamura T.
Organizer
50th Annual Meeting of American Society Of Clinical Oncology
Place of Presentation
Chicago, Illinois
Year and Date
2014-05-30 – 2014-06-03
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[Presentation] Comparison of treatment invasiveness between upfront debulking surgery versus interval debulking surgery following neoadjuvant chemotherapy for stage III/IV ovarian, tubal, and peritoneal cancers in phase III randomized trial: JCOG0602. ASCO 2014,2014
Author(s)
Onda T, Yoshikawa H, Shibata T, Nakamura K, Satoh T, Saito T, Kasamatsu T, Nakanishi T, Nogawa T, Saitou M, Ushijima K, Kobayashi H, Takano T, Kawana K, Yokota H, Takano M, Takeshima N, Yaegashi N, Konishi I, Kamura T, japan clinical Oncology Group.
Organizer
50th Annual Meeting of American Society Of Clinical Oncology
Place of Presentation
Chicago, Illinois
Year and Date
2014-05-30 – 2014-06-03
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