Effect of immunosuppressive agents on the interaction between keloid fibroblasts and CD4+ T cells in a coculture model

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670745
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Hokkaido University
• Principal Investigator: YAMAMOTO Yuhei 北海道大学, 医学(系)研究科(研究院), 教授 (70271674)
• Co-Investigator(Kenkyū-buntansha): FURUKAWA Hiroshi 北海道大学, 大学院医学研究科, 准教授 (00399924) ; OYAMA Akihiko 北海道大学, 北海道大学病院, 講師 (70374486) ; FUNAYAMA Emi 北海道大学, 大学院医学研究科, 講師 (10533630) ; HAYASHI Toshihiko 北海道大学, 大学院歯学研究科, 准教授 (00432146) ; MURAO Naoki 北海道大学, 北海道大学病院, 助教 (90706558)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ケロイド / 免疫抑制剤

Outline of Final Research Achievements

Keloid is an inflammatory and fibrotic disease. To modulate inflammation is an important approach for the treatment of keloids. We investigated the effect of immunosuppressive agents on the interaction between keloid fibroblasts and CD4+ T cells in a coculture system. Our results suggest that the agents may affect keloid formation by modulating inflammation and directly affecting keloid fibroblasts.

Free Research Field

創傷治癒学