2014 Fiscal Year Final Research Report
Elucidation of pro-metastatic property of interferon degradation
| Project/Area Number |
25670841
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Tsurumi University (2014)
Tohoku University (2013) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHINOHARA Fumiaki 東北大学, 歯学研究科, 非常勤講師 (80400258)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | インターフェロン / 腫瘍免疫 / サイトカイン / 破骨細胞 / ADAM１７ / TACE |
|---|
| Outline of Final Research Achievements |
ADAM family enzymes, which are highly expressed in cancer cells, were reported as the prognostic factor of tumor. In addition, some cancer cells favor to metastasize into bone marrow through the induction of osteoclastic bone resorption around cancer cells.
In the present study, we investigated the degradation mechanism of interferon gamma, which shows anti-osteoclastogenic and anti-tumorigenic property, by cancer cells. We discovered ADAM 17 degrades interferon gamma for the first time.
|
| Free Research Field |
骨代謝
|
