高齢者の発話行為の理解と記憶定着における情動機能：脳機能イメージング研究

2015 Fiscal Year Annual Research Report

• Project/Area Number: 25704009
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: 木山 幸子 国立研究開発法人国立長寿医療研究センター, 健康長寿支援ロボットセンター, 研究員 (10612509)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 感情語 / 文再認 / 加齢変化 / ポジティビティ効果 / fMRI

Outline of Annual Research Achievements

円満な社会生活を送る上で他者との関わりを維持することは不可欠である。齟齬なく他者との意志疎通を図り共同行為を成功させるためには、話し手が情報を正しく伝えるだけではなく、聞き手がその情報を確実に記憶に定着させ行為の実現に貢献しなければならない。
言語性作業記憶（verbal working memory）には、感情の効果が認められるという。「うれしい」「かなしい」等の感情語の再認の成績は中立語よりよいことが報告されている（Levens & Phelps, 2008）。本若手A課題では、与えられた文を理解し記憶に定着させる際の肯定的/否定的感情語の果たす役割の神経基盤について、磁気共鳴機能画像法 (functional magnetic resonance imaging: fMRI) を通して検討した。
行動データとfMRIデータの分析の結果、その文が先の文処理課題で提示されたものであったか否かを問う文再認課題遂行中の脳機能において、感情効果が認められた。肯定語を含む文の再認では、中立語を含む文に比べて両側眼窩回の活動が亢進した。否定語を含む文は、中立語文に比べて左眼窩回、右中側頭回、左嗅皮質、右紡錘状回が賦活した（p < .001 uncorrected, k = 50 voxels）。
文を再認する際の感情語の働きは、主に大脳辺縁系の周辺に認められることが観察された。肯定/否定両条件の感情語に眼窩回が関わることは、単語再認課題における感情効果の神経基盤を検討した先行研究と一致する (Maddock, et al., 2003)。さらに、とりわけ否定的感情語を含む文の再認において、嗅皮質や紡錘状回など辺縁系のより広範囲での亢進が見られた。若年者は、文の再認において、肯定的感情語より否定的感情語に強く反応することが示唆される。

Research Products

• [Int'l Joint Research] York University(Canada)
  • Country Name: Canada
  • Counterpart Institution: York University
• [Int'l Joint Research] Nanyang Technological University/National University of Singapore(Singapore)
  • Country Name: Singapore
  • Counterpart Institution: Nanyang Technological University/National University of Singapore
• [Int'l Joint Research] Georgia State University(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Georgia State University
• [Int'l Joint Research] Leiden University(オランダ)
  • Country Name: NETHERLANDS
  • Counterpart Institution: Leiden University
• [Journal Article] Involvement of the ventrolateral prefrontal cortex in learning others’ bad reputations and indelible distrust. (2016)
  • Author(s): Suzuki, A., Ito, Y., Kiyama, S., Kunimi, M., Ohira, H., Kawaguchi, J., Tanabe, H. C., & Nakai, T.
  • Journal Title: Frontiers in Human Neuroscience Volume: 10 Pages: 1-13
  • DOI: org/10.3389/fnhum.2016.00028
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Investigation of age-related changes in brain activity during the divalent task-switching paradigm using functional MRI. (2016)
  • Author(s): Kunimi, M., Kiyama, S., & Nakai, T.
  • Journal Title: Neuroscience Research Volume: 103 Pages: 18-26
  • DOI: 10.1016/j.neures.2015.06.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 中国語を母語とする日本語学習者による流行語の理解 (2015)
  • Author(s): 張セイイ・木山幸子・玉岡賀津雄
  • Journal Title: Language Education and Technology Volume: 51 Pages: 31-49
  • Peer Reviewed
• [Presentation] Training effect of speech articulation on older speakers as revealed by fMRI (2016)
  • Author(s): Kiyama, S., Suzuki, A., Chen, S-H. A., & Nakai, T.
  • Organizer: The 22nd Annual Meeting of the Organization for Human Brain Mapping (OHBM).
  • Place of Presentation: Palexpo Exhibition and Congress Centre, Geneva, Switzerland.
  • Year and Date: 2016-06-26 – 2016-06-30
  • Int'l Joint Research
• [Presentation] Plastic-adaptive changes after articulatory training in the elderly: An fMRI study. (2016)
  • Author(s): Kiyama, S., Suzuki, A., Chen, S-H. A., & Nakai, T.
  • Organizer: 24th ISMRM (International Society for Magnetic Resonance in Medicine) Annual Meeting & Exhibition.
  • Place of Presentation: Suntec Singapore Convention & Exhibition Centre, Singapore.
  • Year and Date: 2016-05-07 – 2016-05-13
  • Int'l Joint Research
• [Presentation] 調音において意味処理が果たす役割：fMRI による脳活動の検討 (2015)
  • Author(s): 渡邉 朋貴・吉田 将人・木山 幸子・中井 敏晴・礒田 治夫
  • Organizer: 平成27年度日本生体医工学会東海支部学術集会
  • Place of Presentation: スズケン本社, 愛知.
  • Year and Date: 2015-10-18 – 2015-10-18
• [Presentation] Classification of age-related brain connectivity using resting state fMRI and the support vector machine. (2015)
  • Author(s): Iidaka, T., Bagarinao, E., Kiyama, S., Kunimi, M., & Nakai, T.
  • Organizer: Society for Neuroscience 2015 45th Annual Meeting
  • Place of Presentation: McCormick Place, Chicago, the U.S.
  • Year and Date: 2015-10-17 – 2015-10-21
  • Int'l Joint Research
• [Presentation] An attempt to correlate the behavioral data during virtual object transfer task performance. (2015)
  • Author(s): Nakai, T., Kunimi, M., Kiyama, S., Tanaka, A., & Chen, S-H. Annabel.
  • Organizer: Neuroinformatics 2015.
  • Place of Presentation: Pullman Cairns International, Cains, Australia.
  • Year and Date: 2015-08-20 – 2015-08-22
  • Int'l Joint Research
• [Presentation] 終助詞「ね」の可変性と心の理論: 事象関連電位による探索的研究 (2015)
  • Author(s): 木山幸子・Verdonschot, S.・熊可欣・Timmer, K.・玉岡賀津雄
  • Organizer: 第150回日本言語学会春季大会
  • Place of Presentation: 大東文化大学, 東京
  • Year and Date: 2015-06-20 – 2015-06-21
• [Presentation] Investigation of the task load-dependent physiological response using simultaneous measurement of pupil dilation and BOLD signal. (2015)
  • Author(s): Kunimi, M., Matsuda, K., Kiyama, S., Takashima, I., & Nakai, T.
  • Organizer: 2015 Organization of Human Brain Mapping (OHBM) Annual Meeting.
  • Place of Presentation: Hawaii Convention Center, Hawaii, the U.S.
  • Year and Date: 2015-06-14 – 2015-06-18
  • Int'l Joint Research
• [Presentation] The correlation between behavioral performance and resting state network activation. (2015)
  • Author(s): Nakai, T., Kunimi, M., Kiyama, S., Tanaka, A., & Chen, S-H. Annabel.
  • Organizer: 2015 Organization of Human Brain Mapping (OHBM) Annual Meeting.
  • Place of Presentation: Hawaii Convention Center, Hawaii, the U.S.
  • Year and Date: 2015-06-14 – 2015-06-18
  • Int'l Joint Research
• [Presentation] Functional connectivity in task switching paradigm. (2015)
  • Author(s): Kunimi, M., Kiyama, S., & Nakai, T.
  • Organizer: 23rd ISMRM (International Society for Magnetic Resonance in Medicine) Annual Meeting & Exhibition.
  • Place of Presentation: Hawaii Convention Center, Hawaii, the U.S.
  • Year and Date: 2015-06-14 – 2015-06-18
  • Int'l Joint Research
• [Presentation] The dmPFC gray matter density enhances elderly’s positivity effect in emotional sentence retrieval. (2015)
  • Author(s): Kiyama, S., Kunimi, M., Verdonschot, R., Tamaoka, K., & Nakai, T.
  • Organizer: 2015 Organization of Human Brain Mapping (OHBM) Annual Meeting.
  • Place of Presentation: Hawaii Convention Center, Hawaii, the U.S.
  • Year and Date: 2015-06-14 – 2015-06-16
  • Int'l Joint Research
• [Presentation] 大脳基底核のポジティビティ効果との関わり：言語処理における加齢変化 (2015)
  • Author(s): 木山幸子・國見充展・玉岡賀津雄・Verdonschot, R.・中井敏晴
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋国際会議場, 愛知.
  • Year and Date: 2015-05-07 – 2015-05-09
• [Presentation] fMRI/瞳孔反射同時計測パラダイムによる課題負荷の上昇に伴う生理的応答の変化に関する研究 (2015)
  • Author(s): 國見充展・松田圭司・木山幸子・高島一郎・中井敏晴
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋国際会議場, 愛知.
  • Year and Date: 2015-05-07 – 2015-05-09
• [Presentation] 視覚運動変換パフォーマンスの加齢変化に関するバイオマーカーとしての脳活動の評価 (2015)
  • Author(s): 中井敏晴・國見充展・木山幸子・田中あゆ子・白石善明
  • Organizer: 第54回日本生体医工学会大会
  • Place of Presentation: 名古屋国際会議場, 愛知.
  • Year and Date: 2015-05-07 – 2015-05-09
• [Presentation] The neural basis for the age-related positivity effect in language processing. (2015)
  • Author(s): Kiyama, S., Kunimi, M., Verdonschot, R., Tamaoka, K., & Nakai, T.
  • Organizer: 23rd ISMRM (International Society for Magnetic Resonance in Medicine) Annual Meeting & Exhibition.
  • Place of Presentation: Toronto, Canada.
  • Year and Date: 2015-05-03 – 2015-05-05
  • Int'l Joint Research
• [Presentation] The effect of behavioral performance during multistep cognitive processing on the extraction of age-related changes from resting state network activation. (2015)
  • Author(s): Nakai, T., Tanaka, A., Kunimi, M., Kiyama, S., & Chen, A. SH.
  • Organizer: 23rd ISMRM (International Society for Magnetic Resonance in Medicine) Annual Meeting & Exhibition.
  • Place of Presentation: Metro Tronto Convention Centre, Toronto, Canada.
  • Year and Date: 2015-05-03 – 2015-05-05
  • Int'l Joint Research