2017 Fiscal Year Final Research Report
Studies on Alkylation Reactions of Arenes without Ortho-directing Groups
| Project/Area Number |
25708006
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2018-03-31
|
| Keywords | ベンゼン / アルケン / アルキル化 / 遷移金属 / ニッケル / 協働触媒 / ルイス酸 / アルミニウム |
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| Outline of Final Research Achievements |
Alkylation reactions of arenes without ortho-directing groups have been investigated using alkenes as alkylating agents. First, we have found that nickel complexes bearing N-heterocyclic carbenes catalyze the reaction of benzene with 1-alkenes with unprecedentedly high linear selectivity to give linear alkylbenzenes. We have also shown that the nickel complexes in combination with aluminum-based Lewis acid cooperatively catalyze para- or meta-selective alkylation of benzenes bearing heteroatom-containing substituents such as aromatic carbonyl compounds, aromatic sulfonyl compounds, and anilides.
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| Free Research Field |
有機合成化学・有機金属化学
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