Pathogenicity and antimicrobial resistance in Enterohepatic Helicobacters

2016 Fiscal Year Final Research Report

• Project/Area Number: 25860105
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental and hygienic pharmacy
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Rimbara Emiko 国立感染症研究所, 細菌第二部, 主任研究官 (20349822)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: ヘリコバクター / ヘリコバクター・シネディ / 薬剤耐性

Outline of Final Research Achievements

Recently H. cinaedi infection has been increasingly reported.
We analyzed the mechanism of antimicrobial resistance in H. cinaedi, and identified the mutations conferring resistance to ciprofloxacin, clarithromycin, and b-lactams. Moreover the role of efflux pumps to the antimicrobial resistance in H. cinaedi was demonstrated. To elucidate the pathogenetic factors in enterohepatic Helicobacters, the genomes of H. fennelliae MRY12-0050, which is the first report for H. fennelliae, and H. cinaedi strain MRY08-1234 caused nosocomial infection , were analyzed. The suspected pathogenetic factors in H. cinaedi have been investigated to understand H. cinaedi pathogenicity.

Free Research Field

細菌学