To develop the personalized dosing system of neuropsychotropic drugs using population pharmacokinetic-pharmacodynamic approach

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860117
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: SARUWATARI Junji 熊本大学, 大学院生命科学研究部(薬), 准教授 (30543409)
• Co-Investigator(Renkei-kenkyūsha): FURUKORI Norio 弘前大学, 大学院医学研究科, 准教授 (20333734) ; ONIKI Kentaro 熊本大学, 大学院生命科学研究部(薬), 助教 (00613407)
• Research Collaborator: ISHITSU Takateru くまもと江津湖療育医療センター, えづこ小児神経発達診療センター, 診療センター長
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 個別医療 / 薬理ゲノム学 / 精神薬理学 / 神経薬理学 / 薬物動態－薬力学解析

Outline of Final Research Achievements

The present study conducted the clinical research to develop the personalized dosing system of neuropsychotropic drugs. Briefly, we investigated the pharmacokinetics and pharmacodynamics (including weight gain as an adverse reactions) of antiepileptic drug: clobazam, mood stabilizers: valproic acid and carbamazepine, antidepressant: paroxetine, antipsychotics: olanzapine, clozapine and risperidone, and we proposed the dosing regimen for these drugs based on the patient information, including genetic polymorphisms and the patient lifestyle.

Free Research Field

臨床薬理学