2014 Fiscal Year Final Research Report
Screening of Alzheimer's desease therapeutic targets based on neprilysin life cycle
| Project/Area Number |
25860251
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KAKIYA NAOMASA 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (20383903)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | アルツハイマー病 / ネプリライシン |
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| Outline of Final Research Achievements |
I have already shown a regulatory mechanism in neprilysin localization dependent on phosphorylation and dephosphorylation. While, I also found out the possibility that phosphorylation of neprilysin may be involved in the metabolism and allosteric activation. In this study, I succeed to reveal the relationship between neprilysin phosphorylation and metabolism.
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| Free Research Field |
生化学
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