2015 Fiscal Year Final Research Report
Analysis of negative selection regulated by medullary thymic epithelial cells
| Project/Area Number |
25860363
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MOURI Yasuhiro 徳島大学, 疾患酵素学研究センター, 助教 (80464353)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | Aire / 負の選択 / 胸腺上皮細胞 |
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| Outline of Final Research Achievements |
We investigated a role of Aire, expressed in medullary thymic epithelial cells, in negative selection using neo self-antigen Tg models. Self-antigens expressed in thymic epithelial cells are (1)directly presented by thymic epithelial cells or (2)indirectly presented by BM-derived antigen presenting cells (BM-APC) such as dendritic cells. Our results suggested Aire is needed in (2)indirect presentation by BM-APC but not (1)direct presentation by thymic epithelial cells. It is thought that Aire regulates antigen presentation by BM-APCs but not thymic epithelial cells in negative selection.
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| Free Research Field |
免疫学
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