Role of inflammation in adipose tissue in the accumulation of ectopic fat

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860403
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Minami Isao 東京医科歯科大学, 医学部附属病院, 助教 (90644196)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 内臓脂肪 / 2型糖尿病 / 筋肉 / 肥満症

Outline of Final Research Achievements

We observed changes in anthropometric and body composition data over a period of 6 months in 68 patients with T2DM. All patients received intensive medical therapy and lifestyle modification, including hospitalization. Visceral fat area (VFA, cm2) and appendicular lean soft tissue (ALST, kg) mass was calculated. Multivariate linear regression analysis revealed that the change in body weight was positively associated with both the changes of VFA and ALST mass. Notably, baseline VFA was an independent positive predictor of the changes in ALST after adjusting for confounding factors such as age, gender, body composition parameters, and A1c. This study revealed that visceral fat accumulation was associated with changes in skeletal muscle mass. These results suggest that visceral fat is predominantly reduced compared with skeletal muscle during weight reduction programs in T2DM patients with visceral obesity.

Free Research Field

内分泌・代謝内科