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2014 Fiscal Year Final Research Report

Investigation of the role of regulatory T cells in atherosclerotic disease

Research Project

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Project/Area Number 25860601
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionKobe University

Principal Investigator

SASAKI NAOTO  神戸大学, 医学(系)研究科(研究院), 助教 (00514746)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywords動脈硬化症 / 炎症 / 免疫細胞
Outline of Final Research Achievements

We provided direct evidence that regulatory T cells (Tregs) prevent atherosclerotic disease by dampening pathogenic immune responses. We also demonstrated that promotion of an endogenous regulatory immune response could be a possible therapeutic approach to prevent the development of atherosclerosis and abdominal aortic aneurysm and induce regression of established atherosclerosis in mice.

Free Research Field

医歯薬学

URL: 

Published: 2016-06-03  

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