2015 Fiscal Year Final Research Report
Identification and characterization of CML stem cell during TKI treatment
| Project/Area Number |
25860796
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 慢性骨髄性白血病 / 白血病幹細胞 / 微小残存病変 / miRNA |
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| Outline of Final Research Achievements |
TKIs have dramatically improved clinical outcomes of the patients with CML-CP. However, even if these patients maintained deep molecular responses, discontinuation of TKI results in early relapse in most cases. Therefore, new therapeutic strategies to eradicate CML stem cells (LSCs) are required to cure CML. We previously identified CD120a, CD225, and CD284 as novel surface molecules on LSCs. Our examination of clinical samples revealed that the detection of these molecules on CD34+CD38- cells might be helpful to evaluate therapeutic effects and to monitor condition changes in CML patients. Also, because TNFα-CD120a-NF-κB signaling promoted LSC proliferation, targeting these molecules may represent an attractive therapeutic approach to eradicate CML stem cells. On the other hands, expression analysis of miRNA which control the level of Abl indicated that epigenetic state of mir-203 promoter was diverse, thereby inducing various expression levels of Bcr/Abl in individual LSCs.
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| Free Research Field |
血液内科学
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