Role of 15-lipoxygenase in the regulation of pulmonary eosinophilic inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860816
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: The Institute of Physical and Chemical Research (2014); The University of Tokyo (2013)
• Principal Investigator: MIYATA Jun 独立行政法人理化学研究所, 統合生命医科学研究センター, 基礎科学特別研究員 (80464866)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 15-リポキシゲナーゼ / 12/15－リポキシゲナーゼ / プロテクチンD1 / DHA / 自然免疫 / 好酸球

Outline of Final Research Achievements

We identified that 12/15-lipoxygenase(12/15-LOX) has protective roles in the regulation of innate type of airway eosinophilic inflammation by using 12/15-LOX gene knockout mice. The numbers of main IL-5-producing lymphocytes were increased in 12/15-LOX knockout mice. Lipidomic analysis of lung revealed large amounts of 12/15-lipoxygenase metabolites during the initiation phase of pulmonary inflammation, which are impaired in 12/15-lipoxygenase knockout mice. We also showed the direct suppressive effects of these 12/15-LOX-derived metabolites on the functions of IL-5-producing lymphocytes.

Free Research Field

呼吸器内科