2014 Fiscal Year Final Research Report
Development of diagnostic test for cutaneous adverse drug reaction.
| Project/Area Number |
25860924
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hokkaido University |
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Principal Investigator |
MURATA Jyunko 北海道大学, 医学(系)研究科(研究院), 客員研究員 (10598387)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 重症薬疹 / 診断マーカー |
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| Outline of Final Research Achievements |
Severe cutaneous adverse drug reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis) are life-threating diseases.
In this project, we investigated to identify diagnostic and prognostic markers using patients’ PBMCs. Patients’ PBMCs were stimulated with causative drugs and mRNA and proteins were collected. These mRNA and proteins profiles were compared to those of non-severe cutaneous adverse drug reactions (maculopapular tyoe).
We identified sFasL and granulysin are the markers.
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| Free Research Field |
皮膚科
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