Imaging method and evaluation method of 3 Tesla MRI diffusion weighted imaging as breast cancer biomarker

2016 Fiscal Year Final Research Report

• Project/Area Number: 25861058
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: Mori Naoko 東北大学, 大学病院, 助教 (90535064)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 拡散強調画像 / 乳癌 / MRI

Outline of Final Research Achievements

In order to clarify the usefulness and measurement method of diffusion weighted images in breast cancer, we showed that the apparent diffusion coefficient (ADC) was significantly different between noninvasive cancer (DCIS) and invasive cancer. Among invasive cancers, a negative correlation between ADC value and cell proliferation index (Ki-Labeling index) was confirmed.
As a measurement method, histogram analysis of the entire tumor volume was performed and compared with the usual ROI method. The average value of the ROI method was confirmed to be a sufficient method as well as the histogram parameters.

Free Research Field

放射線診断学