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2015 Fiscal Year Final Research Report

Anticancer therapy controlling vascular permeability in interventional radiology

Research Project

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Project/Area Number 25861078
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKanazawa University

Principal Investigator

Yoshida Kotaro  金沢大学, 医学系, 助教 (30645130)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords血管透過性 / permeability / IVR
Outline of Final Research Achievements

In this project, we obtained the protocol of noninvasive intravascular interventional approach from femoral artery and catheterization to selective hepatic arteries. In steady condition, there is no sign of extravasation of FITC-dextran injected from hepatic artery. And there is no sign of extravasation of FITX-dextran in the drug administration model of nitroglycerin, sodium nitroprusside, histamine, and platelet activating factor. On the other hand, in liver VX-2 tumor model, the hyper-vascular permeability was observed at the peritumoral area in administration of nitroglycerin.

Free Research Field

放射線科

URL: 

Published: 2017-05-10  

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