Development of new treatments to prevent rupture of intracranial aneurysms

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861279
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: The University of Tokushima
• Principal Investigator: TADA YOSHITERU 徳島大学, ヘルスバイオサイエンス研究部, 助教 (30547964)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 脳動脈瘤破裂 / エストロゲン / くも膜下出血

Outline of Final Research Achievements

The aim of this study was to establish pharmacological treatments for prevention of rupture of intracranial aneurysms. To test pharmacological therapy, we established a rat model of intracranial aneurysms in which spontaneous aneurysm rupture occurred. Female rats were subjected to estrogen deficiency, hemodynamic stress, and renal hypertension. In this model, we demonstrated that endothelial dysfunction, oxidative stress, inflammation, and high salt intake were associated with the formation of intracranial aneurysms. Various types of drugs prevent the formation of intracranial aneurysms. Furthermore, to examine the mechanisms of aneurysmal rupture, we modified this model. In modified model, rats had a higher incidence of aneurysmal rupture. In the future study, we will examine the mechanisms of aneurysmal rupture and test the pharmacological therapy for prevention of aneurysmal rupture.

Free Research Field

医歯薬学