Development of hypoxia-imaging in brain tumors using 7 Tesla MRI

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861287
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Iwate Medical University
• Principal Investigator: UWANO Ikuko 岩手医科大学, 医学部, 助教 (20468317)
• Research Collaborator: KUDO Kohsuke ; OGASAWARA Kuniaki ; BEPPU Takaaki ; SASAKI Makoto
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 7テスラMRI / 定量的磁化率マップ / 酸素摂取率

Outline of Final Research Achievements

In this study, we evaluated the performance and efficacy for intensity inhomogeneity correction of various sequences of the human brain in 7 Tesla MRI using the extended version of the unified segmentation algorithm, and we found all of these intensity inhomogeneities were successfully corrected and the contrast between different tissue types was maintained after inhomogeneity correction. In addition, we investigated whether oxygen extraction fraction (OEF) maps that were generated with a quantitative susceptibility mapping (QSM) technique at 7 Tesla would demonstrate OEF changes in patients with major cerebrovascular steno-occlusive disease compared with OEF maps that were generated with PET, and as a result the OEF ratios on QSM-OEF maps at 7 Tesla correlated well with those on PET-OEF maps in patients with steno-occlusive cerebrovascular diseases.

Free Research Field

医用画像処理・解析