2015 Fiscal Year Final Research Report
Inhibitory effect of oxygen nano-bubble water on urinary stone formation
| Project/Area Number |
25861442
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Hirose Yasuhiko 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (60381894)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | Kidney stone / Inflammation / Oxygen nano-bubble / Hyperoxaluria |
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| Outline of Final Research Achievements |
Kidney stone resembles arteriosclerosis in the mechanism, calcification composition and epidemiology. Water including oxygen nano-bubbles (nanometer-sized bubbles generated from oxygen microbubbles; ONB water) has anti-inflammatory effects. Based on these anti-inflammatory effects, ONB water has been reported as a useful therapy for atherosclerosis. Therefore, we investigated the inhibitory effects of ONB water on kidney stone formation using a hyperoxaluric rat model. Our results suggest that ONB water reduces crystal retention in hyperoxaluric rats due to decreased renal tubular cell injury and resulting expression of crystal binding molecules (osteopontin: OPN and hyaluronic acid: HA).
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| Free Research Field |
医歯薬学 外科系臨床医学・泌尿器科学
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