The functional study about mechanisms of the sacral acupuncture stimulus to overactive bladder, bladder inflammation model rats.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25861456
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Meiji University of Integrative Medicine
• Principal Investigator: HINO KOKORO 明治国際医療大学, 鍼灸学部, 講師 (30555652)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 頻尿 / ラット / カンナビノイド受容体 / 仙骨部 / 鍼刺激

Outline of Final Research Achievements

The aim of this study is to elucidate the mechanisms of sacral acupuncture stimulation for overactive bladder model rats. The intercontraction interval (ICI) was prolonged after sacral acupuncture stimulation in acetic acid-induced bladder irritation (AA) rats and hydrochloric-induced cystitis rats but cychrophosphamide-induced cystitis rats. The effect of sacral acupuncture stimulation might be different from the cause of bladder conditions. The stimulation of moxibution to lower abdomen was more prolonged ICI than sacral stimulation of moxibution in AA rats. The difference of stimulation modalities would affect the effectiveness of stimulation of sacral lesion. Cannabinoid 1 (CB1) receptor inhibitor suppressed the prolonged ICI by sacral acupuncture stimulation in AA rats. It was considered that CB1 receptor could be a part of mechanisms of sacral acupuncture stimulation for overactive bladder.

Free Research Field

泌尿器