2015 Fiscal Year Final Research Report
Cyclic AMP signaling network in the decidualization of endometrial stromal cells
| Project/Area Number |
25861511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 脱落膜化 / EPAC |
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| Outline of Final Research Achievements |
Decidualization (differentiation) of human endometrial stroma and gland development, which are indispensable for the establishment and maintenance of pregnancy are regulated by cyclic AMP-mediated signaling pathway. We demonstrated the cooperative function of canonical protein kinase A and Exchange protein directly activated by cAMP (Epac)-mediated cAMP signaling in decidualization. We also clarified the crucial role of Epac signaling associated factors in decidualization and maturation of endometrial glandular cells.
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| Free Research Field |
生殖内分泌学
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