Investigation for the pathogenic potential of streptolysin S homolog secreted from beta-hemolytic oral streptococci

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861746
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: TABATA Atsushi 徳島大学, ソシオテクノサイエンス研究部, 助教 (10432767)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ストレプトリジンS / 口腔連鎖球菌 / アンギノーサス群連鎖球菌 / β溶血 / 病原因子 / Streptococcus

Outline of Final Research Achievements

In this study, we revealed that a homolog of streptolysin S (SLS), a typical peptide-type hemolytic factor secreted from Pyogenic group streptococci, was the β-hemolytic factor of β-hemolytic Anginosus group streptococci (β-AGS). Moreover, the investigation of cytotoxicity of β-hemolytic S. anginosus subsp. anginosus (β-SAA) dependent on the SLS homolog showed that relatively milder than hemolysis but distinguishable cell damage was induced in human oral squamous cell carcinoma under the co-culture condition with β-SAA. These results suggest the participation of SLS homolog secreted from β-AGS not only in β-hemolysis but also in cytotoxicity of β-AGS.

Free Research Field

医歯薬学