Evaluation of novel antibacterial agents derived from oral cavity against Staphylococcus aureus to inhibit oral colonization.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861749
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Kagoshima University
• Principal Investigator: KAWADA-MATSUO Miki 鹿児島大学, 医歯(薬)学総合研究科, 講師 (20527048)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 黄色ブドウ球菌 / 口腔内定着 / バクテリオシン / 二成分制御系

Outline of Final Research Achievements

We evaluated a novel antibacterial agents against Staphylococcus aureus to inhibit oral colonization. We isolated Streptococcus sanguinis and Streptococcus parasanguinis which have antibacterial actuvuty against S. aureus. These bacteria produce hydrogen peroxide as antibacterial agent. Furthermore, two-component systems of S.aureus are revealed that related to the resistant system against hydrogen peroxide of S. sanguinis and bacteriocins produced by L. lactis and S. warneri. We consider that TCSs can be applied as a fixing inhibitors preventing oral colonization of S. aureus.

Free Research Field

口腔細菌