Bio-active effect of inorganic polyphosphoric to achieve new innovation for bone quality

2014 Fiscal Year Final Research Report

• Project/Area Number: 25861845
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Hiroshima University
• Principal Investigator: MORITA Koji 広島大学, 大学病院, 助教 (30555149)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ポリリン酸 / 骨再生 / 表面形状

Outline of Final Research Achievements

This study was designed to elucidate the effect of HA plate adsorbed with PolyP-65 on proliferation or differentiation of MC3T3-E1 cells. After we confirmed adsorption of PolyP-65 onto the surface of HA plate, Surface roughness, water contact angle of HA plate adsorbed with PolyP-65, and calcium deposition and osteoblast differentiation in MC3T3-E1 culture were evaluated. Within the limited results of this study, it may be concluded that HA plate adsorbed with PolyP-65 at high concentration enhances calcification by binding calcium ion from medium, promoting differentiation of MC3T3-E1 cells.

Free Research Field

補綴学