2015 Fiscal Year Final Research Report
Functional screening of tumor suppressive microRNA and application to nucleic acid medicine
| Project/Area Number |
25861918
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Uesugi Atsushi 東京医科歯科大学, 歯学部附属病院, 医員 (20637061)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 口腔がん / microRNA / 核酸医薬 |
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| Outline of Final Research Achievements |
This study aims for identification of the tumor suppressive microRNA which is available for clinical application as new nucleic acid medicine contributing to cancer personalized medicine.
We transfected synthetic double strand miRNA library into NA,SKN3 oral squamous cell carcinoma cell lines and RT7 immortalization cell line derived from an oral mucosa epithelium .As a result, we recognized cytostasis activity in a cancer cell lines and picked miRNA not to accept on RT7.We perform analysis about the identification of target molecules and the molecular mechanism.
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| Free Research Field |
歯科
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