Elucidation of a mechanism of REG1A works as a chemoradiosensitivity marker in esophageal squamous cell cancer and its intensity

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870072
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery; Tumor diagnostics
• Research Institution: Akita University
• Principal Investigator: Sato Yusuke 秋田大学, 医学(系)研究科(研究院), 講師 (10431628)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 食道癌 / 化学放射線 / 感受性マーカー

Outline of Final Research Achievements

It has been reported that REG1A expression is correlated with advanced stage and poor prognosis in cancers of gastric, colon, breast, lung, pancreas and liver. On the other hand, we have reported that REG1A expression status has the potential to be a highly reliable and clinically useful chemoradiosensitivity marker in patients with advanced thoracic esophageal squamous cell carcinoma. In the present study, we elucidated that REG1A activates c-Jun via the JNK and ERK pathway, thereby enhancing radiosensitivity in esophageal squamous cell cancer. Moreover, we also found that REG1A plays a key role in the upregulation of PD- L1 and that its activities may also include induction of IL- 1β and regulation of the p38 MAPK signal- ing pathway.

Free Research Field

食道癌