The role of the circadian clock in pollen allergy

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870276
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology; Collagenous pathology/Allergology
• Research Institution: University of Yamanashi
• Principal Investigator: NAKAMURA Yuki 山梨大学, 総合研究部, 講師 (90580465)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 花粉症 / 体内時計

Outline of Final Research Achievements

In most pollen allergy patients, symptoms worsen overnight or early in the morning. Although the circadian pathophysiology of pollen allergy is well documented, the biological basis of this phenomenon remain poorly unknown. In this study, "circadian clocks" were directly verifies that involved in the pathogenesis of pollen allergy using allergic rhinitis model. The severity of allergic rhinitis symptoms in wild-type mice showed a time-of-day-dependent variation, whereas, was absent in clock mutant mice. Furthermore, a time-of-day-dependent variation in the severity of allergic rhinitis symptoms observed in wild-type mice was absent by administering a drug that effects on the circadian clocks. A time-of-day-dependent variation in the severity of allergic rhinitis symptoms in the healthy mice was absent in the mouse chronic jet lag model.
These results suggested that "circadian clocks" is involved in pathogenesis of pollen allergy.

Free Research Field

アレルギー学