2014 Fiscal Year Final Research Report
Study on the biosynthesis and the dynamics of archaeal membrane lipids using synthetic lipid probes
| Project/Area Number |
25870381
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
Chemical biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 古細菌 / エーテル型膜脂質 / 化学プローブ / 蛍光ラベル / 脂質生物学 / ケミカルバイオロジー |
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| Outline of Final Research Achievements |
Structure of membrane lipids of Archaea significantly differs from that of Bacteria and Eukarya. In this study, we designed and synthesized archaeal membrane lipid analogs that bear a fluorescent group in order to unveil the biosynthesis and the dynamics of membrane lipids of Archaea. Detailed investigations of synthetic routes achieved a successful synthesis of a fluorescent-labeled archaetidylethanolamine derivative, as well as key synthetic intermediates that enable efficient preparation of archaeal-type fluorescent lipid probes with various polar head groups.
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| Free Research Field |
有機合成化学、生物有機化学
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