2016 Fiscal Year Final Research Report
Implication of lectin proteins for pathogensis of mental disorders.
| Project/Area Number |
25870494
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
Neurochemistry/Neuropharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
Nakabeppu Yusaku
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | ガレクチン-1 / ガレクチン-3 / 統合失調症 / マウス / 海馬 / 介在神経 |
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| Outline of Final Research Achievements |
Galectin (gal) is one of several well-studied proteins among the lectin families which are involved in various biological processes.The purpose of this project is to clarify the relationship between gal and mental disorders. In this study, we reported several new findings as follows: 1) 77% of gal-1-positive cells expressed somatostatin and 79% of gal-1-positive cells expressed GAD67 in the mouse hippocampus, 2)We counted the number of somatostatin-, parvalbumin-, and GAD67-positive cells in the hippocampi of both gal-1 knockout and wild-type mice. However, no significant differences were found, 3)The serum galectin-3 levels were significantly higher in patients with schizophrenia than they were in controls, 4), A significant positive correlation was found between the serum galectin-3 level and the positive symptoms score of the Brief Psychiatry Rating Scale.
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| Free Research Field |
精神医学
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