2014 Fiscal Year Final Research Report
Pathophysiology and therapeutic development for bisphosphonate-related osteonecrosis of the jaw
| Project/Area Number |
25870523
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
Pathobiological dentistry/Dental radiology
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ビスフォスフォネート製剤 / 顎骨壊死 / 免疫 / 骨壊死 / マクロファージ / リンパ管内皮細胞 |
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| Outline of Final Research Achievements |
Bisphosphonate-related osteonecrosis of the jaw (BR-ONJ) mainly occurs following tooth extraction with patients taking oral and/or intravenous bisphosphonates. However, the mechanisms of BR-ONJ is unclear. The aim of this study was to address pathophysiology of BR-ONJ using mouse ONJ model in the combination of intravenous bisphosphonate treatment, chemotherapy and tooth extraction. This model indicated that immune suppression might be associated with BR-ONJ due to some immune-related cells and proteins. This findings may contribute to the development of ONJ therapy.
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| Free Research Field |
口腔外科学
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