Influence of the isolation rearing or the type of exercise on cognitive function in alzheimer's disease model rats.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25870587
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering; Kansei informatics
• Research Institution: Ibaraki Prefectural University of Health Science
• Principal Investigator: Kaku Masami 茨城県立医療大学, 保健医療学部, 嘱託助手 (30646261)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アルツハイマー病 / 参照記憶障害 / ストレス / 社会的孤立

Outline of Final Research Achievements

Alzheimer's disease (AD) is characterised by a progressive impairment of cognitive function. AD model rodents exhibit learning and memory deficits in a variety task. Recently, it is reported that stress intensified memory deficits in AD and AD model animals. Therefore, the fact that the task itself is so stressful makes it difficult to interpret data concerning β-amyloid (Aβ) -induced learning and memory deficits.
I assessed the lereaning and memory in AD model rats by the residential maze task (RMT) and the Barnes maze task (BMT).
I found that Aβ infused rats caused impairment of reference memory (retention period for 5 weeks) in RMT and BMT. Both Aβ and control rats were able to learn each task, but the ability to retention for long time in Aβ infused rats were significantly impaired. These results suggest that a continuous infusion of Aβ induces impairment of memory retention. Additionally, I found that the isolation rearing hastens the onset of reference memory deficit.

Free Research Field

行動神経科学