The study of exocytosis via common pathway of MARCKS phosphorylation in parotid and pancreatic exocrine glands

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870667
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology; Functional basic dentistry
• Research Institution: Dokkyo Medical University
• Principal Investigator: SATOH Keitaro 獨協医科大学, 医学部, 助教 (10549041)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: MARCKS / 唾液腺 / 膵臓 / 外分泌 / 開口放出 / PKC / 腺房細胞 / アミラーゼ

Outline of Final Research Achievements

I investigated the role of Myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in parotid and pancreatic amylase release. This study suggest that MARCKS phosphorylation via the activation of PKCδ is involved in parotid and pancreatic amylase release. In pancreatic acini, MARCKS displacement from the membrane lipid rafts might play a role for exocytosis via regulation of SNARE proteins.

Free Research Field

生理学