2015 Fiscal Year Final Research Report
Identification of a novel ADAMTS9 function for protein transport
| Project/Area Number |
25870759
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
General physiology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ADAMTS9 / ２型糖尿病 / C.elegans |
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| Outline of Final Research Achievements |
It has been reported that an ADAMTS9 gene variant is associated with type 2 diabetes. The underlying pathology of type 2 diabetes is insulin resistance and beta-cell dysfunction. However, the molecular mechanisms underlying ADAMTS9 function in beta cells and peripheral tissues are unknown.
We investigated whether GON-1, the C.elegans homolog of ADAMTS9, is involved in the insulin secretion and insulin signaling in C.elegans. We found that both insulin secretion and the insulin-signaling pathway are compromised by GON-1 depletion. These defects in gon-1 mutants were restored by GON domain expression. These data suggest that the GON domain of GON-1 is involved in protein secretion from insulin secretory cells and in insulin/IGF-like signaling at peripheral tissues.
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| Free Research Field |
細胞生物学
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