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2015 Fiscal Year Final Research Report

Development of the neuron targeting functional peptide-modified nanocarriers for CNS diseases therapy

Research Project

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Project/Area Number 25870767
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Physical pharmacy
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

Takanori Kanazawa  東京薬科大学, 薬学部, 助教 (60434015)

Project Period (FY) 2013-04-01 – 2016-03-31
Keywords脳デリバリー / Nose-to-Brain / 機能性ペプチド / 高分子ミセル / ナノキャリア / 核酸デリバリー
Outline of Final Research Achievements

In this study, to develop the drug/siRNA delivery system to the brain using nasal administration and multifunctional peptide-modified nanocarriers, we designed the novel functional peptide-modified nanocarriers and estimated them about the intracellular siRNA uptake in neuron cells and nose-to-brain delivery of siRNA in rats. The functional peptide-modified nanocarriers strongly increased the intracellular siRNA uptake and siRNA delivery to the brain from nasal cavity. Combination of the funtional peptide-modified nanocarriers and nose-to-brain delivery showed the therapeutic effects in t-MCAO (Transient-Middle Cerebral Artery Occlusion) rats. In conclusion, combination of the funtional peptide-modified nanocarriers and nose-to-brain delivery can be expected as an useful drug delivery system for CNS diseases.

Free Research Field

医療系薬学

URL: 

Published: 2017-05-10  

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