Evaluation on specific adsorption of targeted microbubbles using a piezoelectric resonator

2014 Fiscal Year Final Research Report

• Project/Area Number: 25870901
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Measurement engineering; Medical systems
• Research Institution: Chiba University
• Principal Investigator: YOSHIDA Kenji 千葉大学, フロンティア医工学センター, 助教 (10572985)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: マイクロバブル / 標的指向化 / 抗原・抗体反応 / ビオチン-アビジン結合 / 横波モード圧電共振子 / 水晶共振子 / 共振特性

Outline of Final Research Achievements

In this study for ultrasonic drug delivery system, an ex vivo system for measuring sensitivity of targeted microbubbles to target molecular was established. In the system, a quartz crystal microbalance was employed as a sensing device for detecting both target molecular and bubbles. The physical theoretical model for analyzing the number density of specifically absorbing bubbles was proposed. The model-based analysis enabled to evaluate the concentration of streptavidin as target molecular and the number density of biotinylated microbubbles specifically absorbing the streptavidin. The proposed system shows promise for the application as evaluation system of the sensitivity of targeted microbubbles.

Free Research Field

計測工学